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author:"Holewinski R"

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Current Database

  • EMDB [6]

Current status

  • REL [6]

Sample type

  • Complex [6]
  • Ligand [5]
  • Protein [5]

Organism

  • Mus musculus [6]
  • Homo sapiens [6]
  • Escherichia coli [5]
  • Camelus bactrianus [3]
  • Streptococcus sp. group g [1]

EM Method

  • Single-particle [6]

Resolution

  • ≥ 3Å and < 4Å [1]
  • ≥ 4Å and < 5Å [2]
  • ≥ 5Å and < 6Å [2]
  • ≥ 8Å and < 12Å [1]

Model molecular weight

  • 500-1000 kDa [5]

Release Date

  • 2024 [6]

Author by name

  • Ciancone AM [6]
  • Dearborn AD [6]
  • Graziano G [6]
  • Holewinski R [6]
  • Kumar A [6]
  • Lei H [6]
  • Marcotrigiano J [6]
  • Neufeld EB [6]
  • O'reilly FJ [6]
  • Reimund M [6]
  • Remaley AT [6]

Author by ORCID

  • Marcotrigiano J [6]
  • Kumar A [6]
  • Reimund M [6]

Journal

  • NATURE [6]

Microscope

  • FEI TITAN KRIOS [6]

Electron Source

  • FIELD EMISSION GUN [6]

Film or detector model

  • GATAN K3 BIOCONTINUUM (6K X 4K) [6]

External links

  • ChEBI [5]
  • ChEMBL [5]
  • PDB [5]
  • PDBe-Kb [5]
  • Pfam [5]
  • UniProt [5]
  • AlphaFold DB [4]
  • DrugBank [3]
  • Complex Portal [2]
  • Gene Ontology [1]
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Showing 1 - 6 of 6. Page 1 of 1
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EMD-44442
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3D View
Dimeric form of LDL, LDL receptor and Legobody
Release date: Dec. 25, 2024
Resolution: 8.6 Å
EM Method: Single-particle

Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J

Nature (2025) 638 pp. 829-835 [ Pubmed: 39663455 DOI: doi:10.1038/s41586-024-08223-0 ]

Sample:
  • Apolipoprotein b 100 (Complex from Homo sapiens)
  • Apolipoprotein b 100 on ldl with ldl receptor and legobody (Complex)
  • Legobody fab (Complex from Mus musculus)
  • Legobody mbp/igg-binding protein a/igg-binding protein g fusion (Complex from Escherichia coli)
  • Low-density lipoprotein receptor (Complex from Homo sapiens)
[Show more]
EMD-44443
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3D View
beta/alpha1 region of ApoB 100
Release date: Dec. 25, 2024
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 9bd1
Q-score: 0.221

Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J

Nature (2025) 638 pp. 829-835 [ Pubmed: 39663455 DOI: doi:10.1038/s41586-024-08223-0 ]

Sample:
  • Low density lipoprotein apob 100 (Complex from Homo sapiens)
  • Apolipoprotein b 100 on ldl with ldl receptor and legobody (Complex)
  • Ldl receptor (Complex from Homo sapiens)
  • Apolipoprotein b-100 (516 kDa, Protein from Homo sapiens)
  • Legobody fab (Complex from Mus musculus)
  • Legobody mbp/igg-binding protein a/igg-binding protein g fusion (Complex from Escherichia coli)
  • 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
[Show more]
EMD-44446
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3D View
ApoB 100 beta barrel bound to LDLR beta propeller
Release date: Dec. 25, 2024
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 9bd8
Q-score: 0.241

Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J

Nature (2025) 638 pp. 829-835 [ Pubmed: 39663455 DOI: doi:10.1038/s41586-024-08223-0 ]

Sample:
  • Ldlr (Complex from Homo sapiens)
  • Apob100 (Complex from Homo sapiens)
  • Apolipoprotein b-100 (516 kDa, Protein from Homo sapiens)
  • Low-density lipoprotein receptor (95 kDa, Protein from Homo sapiens)
  • Legobody fab (Complex from Mus musculus)
  • Ldl apob100 bound to ldlr (Complex)
  • Legobody mbp/igg-binding protein a/igg-binding protein g fusion (Complex from Escherichia coli)
  • 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
[Show more]
EMD-44450
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3D View
Middle Region of Apolipoprotein B 100 bound to Low Density Lipoprotein Receptor
Release date: Dec. 25, 2024
Resolution: 4.18 Å
EM Method: Single-particle
Fitted PDBs: 9bde
Q-score: 0.311

Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J

Nature (2025) 638 pp. 829-835 [ Pubmed: 39663455 DOI: doi:10.1038/s41586-024-08223-0 ]

Sample:
  • Calcium ion (40 Da, Ligand)
  • Maltose/maltodextrin-binding periplasmic protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (59 kDa, Protein from Streptococcus sp. 'group G')
  • Middle of apob100 bound to ldl receptor and legobody (Complex)
  • Apob100 nanobody 4 (14 kDa, Protein from Camelus bactrianus)
  • Apolipoprotein b 100 (516 kDa, Protein from Homo sapiens)
  • Low-density lipoprotein receptor (95 kDa, Protein from Homo sapiens)
  • Legobody 8d3 fab heavy chain (25 kDa, Protein from Mus musculus)
  • Legobody 8d3 fab light chain (24 kDa, Protein from Mus musculus)
  • 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
[Show more]
EMD-44469
Download Map
3D View
Apolipoprotein B 100 bound to LDL receptor and legobody
Release date: Dec. 25, 2024
Resolution: 5.4 Å
EM Method: Single-particle
Fitted PDBs: 9bdt
Q-score: 0.198

Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J

Nature (2025) 638 pp. 829-835 [ Pubmed: 39663455 DOI: doi:10.1038/s41586-024-08223-0 ]

Sample:
  • Legobody 8d3 fab light chain (24 kDa, Protein from Mus musculus)
  • Apoliprotein b 100 from ldl bound to ldl receptor and legobody (Complex from Homo sapiens)
  • Maltodextrin-binding protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (59 kDa, Protein from Escherichia coli)
  • Apob100 nanobody 4 (14 kDa, Protein from Camelus bactrianus)
  • Apolipoprotein b-100 (516 kDa, Protein from Homo sapiens)
  • Low-density lipoprotein receptor (95 kDa, Protein from Homo sapiens)
  • Legobody 8d3 fab heavy chain (25 kDa, Protein from Mus musculus)
  • Calcium ion (40 Da, Ligand)
  • 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
[Show more]
EMD-45787
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3D View
Nanobody 4 bound to Apolipoprotein B 100
Release date: Dec. 25, 2024
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 9coo
Q-score: 0.396

Reimund M, Dearborn AD, Graziano G, Lei H, Ciancone AM, Kumar A, Holewinski R, Neufeld EB, O'Reilly FJ, Remaley AT, Marcotrigiano J

Nature (2025) 638 pp. 829-835 [ Pubmed: 39663455 DOI: doi:10.1038/s41586-024-08223-0 ]

Sample:
  • Low-density lipoprotein receptor (88 kDa, Protein from Homo sapiens)
  • Legobody 8d3 fab light chain (24 kDa, Protein from Mus musculus)
  • Maltodextrin-binding protein,immunoglobulin g-binding protein a,immunoglobulin g-binding protein g (59 kDa, Protein from Escherichia coli)
  • Middle of apob100 bound to ldl receptor and legobody (Complex from Homo sapiens)
  • Apob100 nanobody 4 (14 kDa, Protein from Camelus bactrianus)
  • Apolipoprotein b 100 (516 kDa, Protein from Homo sapiens)
  • Legobody 8d3 fab heavy chain (25 kDa, Protein from Mus musculus)
  • Calcium ion (40 Da, Ligand)
  • 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
[Show more]
Sort by: Download
Showing 1 - 6 of 6. Page 1 of 1
Display:
Statistics
×

Download











































Preview first 10
Download

Filter By

Current Database

  • EMDB [6]

Current status

  • REL [6]

Sample type

  • Complex [6]
  • Ligand [5]
  • Protein [5]

Organism

  • Mus musculus [6]
  • Homo sapiens [6]
  • Escherichia coli [5]
  • Camelus bactrianus [3]
  • Streptococcus sp. group g [1]

EM Method

  • Single-particle [6]

Resolution

  • ≥ 3Å and < 4Å [1]
  • ≥ 4Å and < 5Å [2]
  • ≥ 5Å and < 6Å [2]
  • ≥ 8Å and < 12Å [1]

Model molecular weight

  • 500-1000 kDa [5]

Release Date

  • 2024 [6]

Author by name

  • Ciancone AM [6]
  • Dearborn AD [6]
  • Graziano G [6]
  • Holewinski R [6]
  • Kumar A [6]
  • Lei H [6]
  • Marcotrigiano J [6]
  • Neufeld EB [6]
  • O'reilly FJ [6]
  • Reimund M [6]
  • Remaley AT [6]

Author by ORCID

  • Marcotrigiano J [6]
  • Kumar A [6]
  • Reimund M [6]

Journal

  • NATURE [6]

Microscope

  • FEI TITAN KRIOS [6]

Electron Source

  • FIELD EMISSION GUN [6]

Film or detector model

  • GATAN K3 BIOCONTINUUM (6K X 4K) [6]

External links

  • ChEBI [5]
  • ChEMBL [5]
  • PDB [5]
  • PDBe-Kb [5]
  • Pfam [5]
  • UniProt [5]
  • AlphaFold DB [4]
  • DrugBank [3]
  • Complex Portal [2]
  • Gene Ontology [1]